Recent Publications
1: Burke-Kleinman J, Rubianto J, Hou G, Santerre JP, Bendeck MP. Matrix-Binding, N-Cadherin-Targeting Chimeric Peptide Inhibits Intimal Thickening but Not Endothelial Repair in Balloon-Injured Carotid Arteries. Arterioscler Thromb Vasc Biol. 2023 Sep;43(9):1639-1652. doi: 10.1161/ATVBAHA.123.319400. Epub 2023 Jul 6. PMID: 37409527; PMCID: PMC10443629.
2: Bonafiglia QA, Zhou YQ, Hou G, Saha R, Hsu YR, Burke-Kleinman J, Bendeck MP. Deficiency in DDR1 Induces Pulmonary Hypertension and Impaired Alveolar Development. Am J Respir Cell Mol Biol. 2022 Nov;67(5):562-573. doi: 10.1165/rcmb.2022-0124OC. PMID: 35926106.
3: Ngai D, Mohabeer AL, Mao A, Lino M, Bendeck MP. Stiffness-responsive feedback autoregulation of DDR1 expression is mediated by a DDR1-YAP/TAZ axis. Matrix Biol. 2022 Jun;110:129-140. doi: 10.1016/j.matbio.2022.05.004. Epub 2022 May 11. PMID: 35562016.
4: Mohabeer AL, Kroetsch JT, McFadden M, Khosraviani N, Broekelmann TJ, Hou G, Zhang H, Zhou YQ, Wang M, Gramolini AO, Mecham RP, Heximer SP, Bolz SS, Bendeck MP. Deletion of type VIII collagen reduces blood pressure, increases carotid artery functional distensibility and promotes elastin deposition. Matrix Biol Plus. 2021 Sep 29;12:100085. doi: 10.1016/j.mbplus.2021.100085. PMID: 34693248; PMCID: PMC8517381.
5: Ngai D, Lino M, Rothenberg KE, Simmons CA, Fernandez-Gonzalez R, Bendeck MP. DDR1 (Discoidin Domain Receptor-1)-RhoA (Ras Homolog Family Member A) Axis Senses Matrix Stiffness to Promote Vascular Calcification. Arterioscler Thromb Vasc Biol. 2020 Jul;40(7):1763-1776. doi: 10.1161/ATVBAHA.120.314697. Epub 2020 Jun 4. PMID: 32493168; PMCID: PMC7310304.
6: Lino M, Ngai D, Liu A, Mohabeer A, Harper C, Caruso LL, Schroer SA, Fu F, McKee T, Giacca A, Woo M, Bendeck MP. Discoidin domain receptor 1-deletion ameliorates fibrosis and promotes adipose tissue beiging, brown fat activity, and increased metabolic rate in a mouse model of cardiometabolic disease. Mol Metab. 2020 Sep;39:101006. doi: 10.1016/j.molmet.2020.101006. Epub 2020 Apr 28. PMID: 32360427; PMCID: PMC7242876.
7: Xu S, Bala S, Bendeck MP. Discoidin domain receptor 1 deficiency in vascular smooth muscle cells leads to mislocalisation of N-cadherin contacts. Biol Open. 2019 Aug 9;8(8):bio041913. doi: 10.1242/bio.041913. PMID: 31362952; PMCID: PMC6737968.
8: Ngai D, Lino M, Bendeck MP. Cell-Matrix Interactions and Matricrine Signaling in the Pathogenesis of Vascular Calcification. Front Cardiovasc Med. 2018 Dec 7;5:174. doi: 10.3389/fcvm.2018.00174. PMID: 30581820; PMCID: PMC6292870.
9: Lino M, Wan MH, Rocca AS, Ngai D, Shobeiri N, Hou G, Ge C, Franceschi RT, Bendeck MP. Diabetic Vascular Calcification Mediated by the Collagen Receptor Discoidin Domain Receptor 1 via the Phosphoinositide 3-Kinase/Akt/Runt-Related Transcription Factor 2 Signaling Axis. Arterioscler Thromb Vasc Biol. 2018 Aug;38(8):1878-1889. doi: 10.1161/ATVBAHA.118.311238. PMID: 29930002; PMCID: PMC6441610.
10: Sun X, Gupta K, Wu B, Zhang D, Yuan B, Zhang X, Chiang HC, Zhang C, Curiel TJ, Bendeck MP, Hursting S, Hu Y, Li R. Tumor-extrinsic discoidin domain receptor 1 promotes mammary tumor growth by regulating adipose stromal interleukin 6 production in mice. J Biol Chem. 2018 Feb 23;293(8):2841-2849. doi: 10.1074/jbc.RA117.000672. Epub 2018 Jan 3. PMID: 29298894; PMCID: PMC5827455.
11: Zhang X, Bendeck MP, Simmons CA, Santerre JP. Deriving vascular smooth muscle cells from mesenchymal stromal cells: Evolving differentiation strategies and current understanding of their mechanisms. Biomaterials. 2017 Nov;145:9-22. doi: 10.1016/j.biomaterials.2017.08.028. Epub 2017 Aug 15. PMID: 28843066.
12: Sivasubramaniyam T, Schroer SA, Li A, Luk CT, Shi SY, Besla R, Dodington DW, Metherel AH, Kitson AP, Brunt JJ, Lopes J, Wagner KU, Bazinet RP, Bendeck MP, Robbins CS, Woo M. Hepatic JAK2 protects against atherosclerosis through circulating IGF-1. JCI Insight. 2017 Jul 20;2(14):e93735. doi: 10.1172/jci.insight.93735. PMID: 28724798; PMCID: PMC5518558.
13: Durgin BG, Cherepanova OA, Gomez D, Karaoli T, Alencar GF, Butcher JT, Zhou YQ, Bendeck MP, Isakson BE, Owens GK, Connelly JJ. Smooth muscle cell-specific deletion of Col15a1 unexpectedly leads to impaired development of advanced atherosclerotic lesions. Am J Physiol Heart Circ Physiol. 2017 May 1;312(5):H943-H958. doi: 10.1152/ajpheart.00029.2017. Epub 2017 Mar 10. PMID: 28283548; PMCID: PMC5451587.
14: Shobeiri N, Bendeck MP. Interleukin-1β Is a Key Biomarker and Mediator of Inflammatory Vascular Calcification. Arterioscler Thromb Vasc Biol. 2017 Feb;37(2):179-180. doi: 10.1161/ATVBAHA.116.308724. PMID: 28122774.
15: Mori Y, Chiang S, Bendeck MP, Giacca A. Insulin decreases atherosclerotic plaque burden and increases plaque stability via nitric oxide synthase in apolipoprotein E-null mice. Am J Physiol Endocrinol Metab. 2016 Aug 1;311(2):E335-45. doi: 10.1152/ajpendo.00320.2015. Epub 2016 May 24. PMID: 27221119.
16: Krohn JB, Hutcheson JD, Martínez-Martínez E, Irvin WS, Bouten CV, Bertazzo S, Bendeck MP, Aikawa E. Discoidin Domain Receptor-1 Regulates Calcific Extracellular Vesicle Release in Vascular Smooth Muscle Cell Fibrocalcific Response via Transforming Growth Factor-β Signaling. Arterioscler Thromb Vasc Biol. 2016 Mar;36(3):525-33. doi: 10.1161/ATVBAHA.115.307009. Epub 2016 Jan 21. PMID: 26800565; PMCID: PMC4767541.
17: Guo J, Breen DM, Pereira TJ, Dalvi PS, Zhang H, Mori Y, Ghanim H, Tumiati L, Fantus IG, Bendeck MP, Dandona P, Rao V, Dolinsky VW, Heximer SP, Giacca A. The effect of insulin to decrease neointimal growth after arterial injury is endothelial nitric oxide synthase-dependent. Atherosclerosis. 2015 Jul;241(1):111-20. doi: 10.1016/j.atherosclerosis.2015.04.799. Epub 2015 Apr 25. PMID: 25974101
18: Silverman-Gavrila RV, Silverman-Gavrila LB, Bilal KH, Bendeck MP. Spectrin alpha is important for rear polarization of the microtubule organizing center during migration and spindle pole assembly during division of neointimal smooth muscle cells. Cytoskeleton (Hoboken). 2015 Apr;72(4):157-70. doi: 10.1002/cm.21222. Epub 2015 May 25. PMID: 25903931.
19: Staudinger LA, Spano SJ, Lee W, Coelho N, Rajshankar D, Bendeck MP, Moriarty T, McCulloch CA. Interactions between the discoidin domain receptor 1 and β1 integrin regulate attachment to collagen. Biol Open. 2013 Sep 13;2(11):1148-59. doi: 10.1242/bio.20135090. PMID: 24244851; PMCID: PMC3828761.
20: Guo J, Dhaliwall JK, Chan KK, Ghanim H, Al Koudsi N, Lam L, Madadi G, Dandona P, Giacca A, Bendeck MP. In vivo effect of insulin to decrease matrix metalloproteinase-2 and -9 activity after arterial injury. J Vasc Res. 2013;50(4):279-88. doi: 10.1159/000351611. Epub 2013 Jul 9. PMID: 23988659.
21: Lopes J, Adiguzel E, Gu S, Liu SL, Hou G, Heximer S, Assoian RK, Bendeck MP. Type VIII collagen mediates vessel wall remodeling after arterial injury and fibrous cap formation in atherosclerosis. Am J Pathol. 2013 Jun;182(6):2241-53. doi: 10.1016/j.ajpath.2013.02.011. Epub 2013 Apr 6. PMID: 23567639; PMCID: PMC3668035.